![]() Senna leaf extract syrup (176 mg/5 mL senna leaf extract): Note: Senna leaf extract is considered a dietary supplement and is not interchangeable on a mL-to-mL (or mg-to-mg) basis with other senna products that contain sennosides.ġ0 to 15 mL (352 to 528 mg senna leaf extract) once daily (preferably at bedtime) may increase to 10 to 15 mL (352 to 528 mg senna leaf extract) twice daily if needed maximum daily dose: 30 mL/ day Dosing: Geriatric Syrup (8.8 mg sennosides/5 mL): 10 to 15 mL (17.6 mg to 26.4 mg sennosides) once daily maximum: 15 mL (26.4 mg sennosides) twice daily.Ĩ.6 mg sennosides/tablet: Two tablets (17.2 mg sennosides) once daily maximum: 4 tablets (34.4 mg sennosides) twice dailyġ5 mg sennosides/tablet: Two tablets (30 mg sennosides) once or twice dailyġ7.2 mg sennosides/tablet: One tablet (17.2 mg sennosides) once daily maximum: 2 tablets (34.4 mg sennosides) twice dailyĢ5 mg sennosides/tablet: Two tablets (50 mg sennosides) once or twice daily Note: Several types of senna products are available on the market and multiple formulations exist that are not equivalent products composed of sennosides are considered OTC medications senna pod concentrate and senna leaf extract are considered dietary supplements and are not interchangeable on a mL-to-mL (or mg-to-mg) basis with other senna products that contain sennosides close attention must be paid to the product description and concentration when ordering or administering. However, senna may be used in select situations. Additional data may be necessary to further define the role of senna as an adjunct in colonic cleansing before colonoscopy.īased on the recommendations for Optimizing Adequacy of Bowel Cleansing for Colonoscopy, the US Multi-Society Task Force on Colorectal Cancer by the American College of Gastroenterology, American Gastroenterological Association, and the American Society for Gastrointestinal Endoscopy, the use of adjunctive agents for precolonoscopy cleansing of the mucosa such as simethicone, flavored electrolyte solutions (eg, Gatorade), prokinetics, spasmolytics, bisacodyl, senna, olive oil, and probiotics is not recommended for routine use since none have consistently shown improved efficacy, safety, or tolerability of the bowel preparation. While the advantage of a lower amount of PEG solution with the use of senna is tolerated better by patients, the lower volumes of PEG solution may reduce the quality of the bowel preparation as was seen in one randomized controlled trial Hookey 2006. Oral: Within 6 to 24 hours Use: Labeled IndicationsĬonstipation: Relieves occasional constipation (irregularity) generally causes bowel movement in 6 to 12 hours Use: Off LabelĬolonic cleansing before colonoscopy (adjunct)cĭata from one uncontrolled study evaluating the use of senna as an adjunct to reduce the amount of polyethylene glycol (PEG) solution necessary suggests that the use of senna as an adjunct in this setting may be beneficial Iida 1992. Pharmacokinetics/Pharmacodynamics Metabolism Stimulant laxatives typically induce defecation by stimulating peristaltic activity on the intestine by direct action on intestinal mucosa or nerve plexus, therefore increasing motility. ![]() ![]() The anthraquinone group of stimulant laxatives includes the plant-derived agents such as senna. Excipient information presented when available (limited, particularly for generics) consult specific product labeling. ![]()
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